Hi Jon,
The Enterprise version has no limits afaik , I have had in my company data sets with 80+ columns, which worked out just fine. I would however recommend, out of my own experience, that you reduce the numbers and keep it manageable - 20-30 works well for me.
The other benefit is the flow is better structured and much more efficient and faster to execute.
On the Wrangler side, there's usually not much argument to keep many columns. Since you have to be below 100MB of data it's rarely an issue. Otherwise above point still applies for the desktop wrangler.
I hope that helped a bit. If you are interested, I can post more about the best practices we used to keep the amount of columns in a manageable size.
